Renal tubular acidosis types

Features of different types of renal tubular acidosis

 renal  metabolic  MRCP

Type 1 RTAType 2 RTAType 4 RTA
LocationDistal tubulesProximal tubulesAdrenal
Acidosis degreeYes (severe)YesMild when present
PotassiumHypokalaemiaHypokalaemiaHyperkalaemia
PathophysiologyFailure of H+ secretion by the alpha intercalated cellsFailed bicarbonate reabsorption from the urine by the proximal tubular cellsDeficiency of aldosterone, or a resistance to its effects, (hypoaldosteronism or pseudohypoaldosteronism)
RadiologyNephrocalcinosisOsteomalacia or rickets
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